Axitinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s... more
Product information "Axitinib"
Description: Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRbeta, respectively. Target: PDGFR, VEGFR, c-Kit. Smiles: C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(SC4=C(C(NC)=O)C=CC=C4)=CC3)NN2. References: Hu-Lowe DD, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008 Nov 15,14(22):7272-83.
| Keywords: | AG-013736 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1452 |
Properties
| Application: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| MW: | 386.47 D |
| Formula: | C22H18N4OS |
Database Information
| CAS : | 319460-85-0| Matching products |
| KEGG ID : | K05096 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H400 |
| P Phrases: | P264, P270, P273, P330, P391, P301+P310, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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