Avibactam (sodium salt)

Avibactam is a beta-lactamase inhibitor (IC50s = 8, 80, and 38 nM for TEM-1, P99, and KPC-2 beta-lactamases, respectively). It restores the antimicrobial activity of ceftazidime (Cay-14828), ceftriaxone (Cay-18866), imipenem (Cay-16039), and piperacillin (Cay-20766) against antibiotic-resistant Enterobacteriaceae in vitro (MIC90 reduction 4-1,024-fold across 190 E. coli and K. pneumoniae clinical isolates). Formulations containing avibactam have been used to treat carbapenem-resistant Enterobacteriaceae infections.Formal Name: sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, monosodium salt. CAS Number: 1192491-61-4. Synonyms: AVE-1330A, NXL104. Molecular Formula: C7H10N3O6S . Na. Formula Weight: 287.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: NC([C@H]1[N@@](C2)C(N(OS([O-])(=O)=O)[C@@H]2CC1)=O)=O.[Na+]. InChi Code: InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15,/h4-5H,1-3H2,(H2,8,11)(H,13,14,15),/q,+1/p-1/t4-,5+,/m1./s1. InChi Key: RTCIKUMODPANKX-JBUOLDKXSA-M.