Aurora Kinase Inhibitor II

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 µM). In MCF-7 cells, it blocks proliferation with an IC50 value of 1.25 µM.Formal Name: N-[4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenyl]-benzamide. CAS Number: 331770-21-9. Synonyms: 4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline. Molecular Formula: C23H20N4O3. Formula Weight: 400.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 2.5 mg/ml. lambdamax: 223, 262, 354 nm. SMILES: COC1=C(OC)C=C(C(NC2=CC=C(NC(C3=CC=CC=C3)=O)C=C2)=NC=N4)C4=C1. InChi Code: InChI=1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26). InChi Key: IMYVCWQAHSYYOO-UHFFFAOYSA-N.