Aureusimine B

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.Formal Name: 3-(1-methylethyl)-6-(phenylmethyl)-2(1H)-pyrazinone. CAS Number: 170713-71-0. Synonyms: Phevalin. Molecular Formula: C14H16N2O. Formula Weight: 228.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CC(C)C1=NC=C(NC1=O)CC2=CC=CC=C2. InChi Code: InChI=1S/C14H16N2O/c1-10(2)13-14(17)16-12(9-15-13)8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,16,17). InChi Key: CZUORGWXUVRUMV-UHFFFAOYSA-N.