Atabecestat
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active beta-site... more
Product information "Atabecestat"
Description: Atabecestat (JNJ-54861911) is a potent, brain-penetrant, and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor that achieves robust and high CSF Abeta reduction, is well-tolerated, and displays sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1]. Target: BACE. Smiles: C[C@]1(C=CSC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F. References: Timmers M, et al. Profiling the dynamics of CSF and plasma Abeta reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.Alzheimers Dement (N Y). 2016 Aug 24,2(3):202-212.
| Keywords: | RSC-385896, JNJ-54861911 |
| Supplier: | TargetMol |
| Supplier-Nr: | T14338 |
Properties
| Application: | Targets beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] (BACE1) |
| MW: | 367.4 D |
| Formula: | C18H14FN5OS |
Database Information
| CAS : | 1200493-78-2| Matching products |
| KEGG ID : | K04521 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H361, H373 |
| P Phrases: | P201, P202, P260, P280, P314, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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