AT7519 (hydrochloride)

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and 50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3beta by down-regulating GSK3beta phosphorylation, which contributes to AT7519-induced apoptosis.Formal Name: 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride. CAS Number: 902135-91-5. Molecular Formula: C16H17Cl2N5O2 . HCl. Formula Weight: 418.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 268 nm. SMILES: O=C(NC1CCNCC1)C2=NNC=C2NC(C3=C(Cl)C=CC=C3Cl)=O.Cl. InChi Code: InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9,/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24),1H. InChi Key: PAOFPNGYBWGKCO-UHFFFAOYSA-N.