Ascorbyl Palmitate

Ascorbyl palmitate is a lipophilic derivative of ascorbic acid (Cay-14656) with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 µmol per 200 µl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics.Formal Name: L-ascorbic acid, 6-hexadecanoate. CAS Number: 137-66-6. Synonyms: Ascorbylpalmitic Acid, NSC 402451. Molecular Formula: C22H38O7. Formula Weight: 414.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 246 nm. SMILES: CCCCCCCCCCCCCCCC(OC[C@H](O)[C@@]1([H])OC(C(O)=C1O)=O)=O. InChi Code: InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1. InChi Key: QAQJMLQRFWZOBN-LAUBAEHRSA-N.