Ascorbic acid 6-palmitate

Ascorbic acid 6-palmitate is fat-soluble form of vitamin C formed from ascorbic acid and palmitic acid and not naturally found in food sources. It is used as a source of vitamin C and as food preservative (E number E304) for stabilization fats and oils, reducing the rate of. It is also used as preservative in pharmaceuticals and cosmetics. Ascorbic acid 6-palmitate has antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays and inhibits lipid peroxidation. It has been shown that despite its antioxidant properties, ascorbic acid 6-palmitate promotes LPO, JNK activation and cytotoxicity following UVB irradiation. Ascorbic acid 6-palmitate effectively inhibited anthrax cytotoxic protease and blocks proteolytic activities of host furin, cathepsin B and caspases that mediate toxin's lethality in cells. It is broad-spectrum and reduces cellular sensitivity to other bacterial toxins that require the same host proteases. Product References (1) W.M. Cort, J. Am. Oil Chem. Soc. 51, 321 (1974) , (2) R.C. Smart & C.L. Crawford, Am. J. Clin. Nutr. 54, 1266S (1991) , (3) H. Chen & A.L. Tappel, Free Radic. Res. 22, 177 (1995) , (4) N. Perricone, et al., BBRC 262, 661 (1999) , (5) O. Yilmaz, et al., J. Cell Biochem. 86, 530 (2002) , (6) A. Meves, et al., J. Invest. Dermatol. 119, 1103 (2002) , (7) K.M. Lee, et al., Mutat. Res. 660, 51 (2009) , (8) S.K. Karmee, Appl. Microbiol. Biotechnol. 81, 1013 (2009) (Review) , (9) R. Mohamed, et al., J. Pharm. Pharmacol. 66, 769 (2014) , (10) L. Zilbermintz, et al., Sci. Rep. 6, 34846 (2016). Appearance: Light yellow powder. Solubility: Soluble in DMSO (30mg/ml), DMF (30mg/ml) or ethanol (10mg/ml). Identity: Determined by 1H-NMR. InChi Key: QAQJMLQRFWZOBN-UWJYYQICSA-N Smiles: OC1=C(O)C(O[C@@]1([H])[C@H](COC(CCCCCCCCCCCCCCC)=O)O)=O