Articaine (hydrochloride)

Most local anesthetics act by abolishing voltage-gated sodium channel currents indiscriminately in all populations of neurons. Articaine is an amide local anesthetic most commonly used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine is reported to modify cardiac action potentials and ion currents only at concentrations higher than the therapeutic range needed to inhibit voltage-gated sodium channels.Formal Name: 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid, methyl ester, monohydrochloride. CAS Number: 23964-57-0. Synonyms: Carticaine, HOE 045, HOE 40045. Molecular Formula: C13H20N2O3S . HCl. Formula Weight: 320.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 274 nm. SMILES: CC1=CSC(C(OC)=O)=C1NC(C(C)NCCC)=O.Cl. InChi Code: InChI=1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4,/h7,9,14H,5-6H2,1-4H3,(H,15,16),1H. InChi Key: GDWDBGSWGNEMGJ-UHFFFAOYSA-N.