ARRY-382

ARRY-382 is an inhibitor of the colony-stimulating factor 1 receptor (CSF1R, IC50 = 9 nM). It is selective for CSF1R over PDGFR, c-Kit, and FMS-related tyrosine kinase 3 (FLT3, IC50s = >10,000 nM for all). ARRY-382 (10 µM) induces apoptosis in several primary human chronic lymphocytic leukemia (CLL) cell lines. It also enhances the cytotoxicity of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (Cay-16274) and PI3K p110delta inhibitor idelalisib (CAL-101, Cay-15279) in several primary human CLL cell lines when used at concentrations ranging from 0.15625 to 10 µM.Formal Name: N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-7-[2-(4-methyl-1-piperazinyl)ethoxy]-imidazo[1,2-a]pyridine-3-carboxamide. CAS Number: 1313407-95-2. Molecular Formula: C32H36N8O2. Formula Weight: 564.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O=C(C1=CN=C2C=C(C=CN21)OCCN3CCN(CC3)C)NC4=CC=CC5=C4C(C6CC6)=NN5CC7=CC=CC(C)=N7. InChi Code: InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41). InChi Key: JUPOTOIJLKDAPF-UHFFFAOYSA-N.