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Aripiprazole is an atypical antipsychotic. It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg. Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette's disorder.Formal Name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone. CAS Number: 129722-12-9. Synonyms: OPC 31, OPC 14597. Molecular Formula: C23H27Cl2N3O2. Formula Weight: 448.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2), (1:7): 0.12 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 216, 255 nm. SMILES: ClC1=CC=CC(N2CCN(CCCCOC3=CC=C(CCC(N4)=O)C4=C3)CC2)=C1Cl. InChi Code: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29). InChi Key: CEUORZQYGODEFX-UHFFFAOYSA-N.
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