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Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties. It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM). Arbutin (50 µM) inhibits hemolysis induced by the free radical generator AAPH (Cay-82235) in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 µM. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1beta, IL-6, and TNF-alpha levels in lung tissue and serum. Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.Formal Name: 4-hydroxyphenyl beta-D-glucopyranoside. CAS Number: 497-76-7. Synonyms: beta-Arbutin, NSC 4036. Molecular Formula: C12H16O7. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 221, 283 nm. SMILES: OC[C@H]1O[C@@H](OC2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1. InChi Key: BJRNKVDFDLYUGJ-RMPHRYRLSA-N.
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