AR-C 155858

AR-C 155858 is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT2 (Kis = 2.3 and Xenopus oocytes expressing the human receptors). It is selective for MCT1 and MCT2 over MCT4 (Ki = >10 µM). AR-C 155858 inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM, respectively).Formal Name: 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione. CAS Number: 496791-37-8. Molecular Formula: C21H27N5O5S. Formula Weight: 461.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: CN(C(C(C(C(N1OC[C@@H](O)C1)=O)=C(CC2=C(C)NN=C2C)S3)=C3N4CC(C)C)=O)C4=O. InChi Code: InChI=1S/C21H27N5O5S/c1-10(2)7-25-20-17(18(28)24(5)21(25)30)16(19(29)26-8-13(27)9-31-26)15(32-20)6-14-11(3)22-23-12(14)4/h10,13,27H,6-9H2,1-5H3,(H,22,23)/t13-/m0/s1. InChi Key: ISIVOJWVBJIOFM-ZDUSSCGKSA-N.