APY-29

APY-29 is a modulator of inositol requiring enzyme 1 alpha (IRE1alpha), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress. It binds to the ATP-binding site on IRE1alpha, where it inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). In vitro, it restores the ability of dephosphoylated IRE1alpha to cleave XBP1 mRNA in a dose-dependent manner. It also enhances IRE1alpha oligomerization in a crosslinking assay.Formal Name: N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine. CAS Number: 1216665-49-4. Molecular Formula: C17H16N8. Formula Weight: 332.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 15 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 249, 273, 306 nm. SMILES: C1(NC2=NNC(C3CC3)=C2)=CC=NC(NC4=CC=C(N=CN5)C5=C4)=N1. InChi Code: InChI=1S/C17H16N8/c1-2-10(1)13-8-16(25-24-13)22-15-5-6-18-17(23-15)21-11-3-4-12-14(7-11)20-9-19-12/h3-10H,1-2H2,(H,19,20)(H3,18,21,22,23,24,25). InChi Key: WJNBSTLIALIIEW-UHFFFAOYSA-N.