Apratastat

Item number	Size	Delivery time	Price
TGM-T14312-1mg	1 mg	7 - 10 business days*	147.00€
TGM-T14312-5mg	5 mg	7 - 10 business days*	608.00€
TGM-T14312-10mg	10 mg	7 - 10 business days*	1,128.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Description: Apratastat is an orally active, potent, and reversible dual inhibitor of tumor... more

Close menu

Product information "Apratastat"

Description: Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-alpha converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-alpha in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1]. Target: MMP, TNF. Smiles: CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1. References: Shu C, et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. J Clin Pharmacol. 2011 Apr,51(4):472-81.

Supplier:	TargetMol
Supplier-Nr:	T14312

Properties

Application:	Targets disintegrin and metalloproteinase domain-containing protein 17 (ADAM17, TACE, CD156b)
MW:	414.5 D
Formula:	C17H22N2O6S2

Database Information

CAS :	287405-51-0\| Matching products
KEGG ID :	K06059 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

Information about the product reference will follow. more

Close menu

You will get a certificate here

Go back

Read, write and discuss reviews... more

Close menu

Customer review for "Apratastat"

Write a review