Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
![Apicidin](https://www.biomol.com/media/image/87/88/af/Cay10575-1_600x600.png)
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Apicidin is a cyclic tetrapeptide that has been found in F. pallidoroseum and has diverse... more
Product information "Apicidin"
Apicidin is a cyclic tetrapeptide that has been found in F. pallidoroseum and has diverse biological activities. It is active against E. tenella, T. gondii, P. falciparum, C. parvum, N. caninum, B. jellisoni, and C. bigenetica (MICs = 62, 8, 125, 30, 15, 4, and 8 ng/ml, respectively) and decreases the percentage of P. berghei-infected erythrocytes in a mouse model of malaria when administered at a dose of 25 mg/kg. Apicidin inhibits histone deacetylase (HDAC) activity in E. tenella homogenates (IC50 = 0.7 nM) and recombinant human HDAC2 and HDAC3 (EC50s = 120 and 43 nM, respectively). It inhibits the proliferation of SKOV3 ovarian cancer cells (EC50 = 1-2.5 µM) and induces cell cycle arrest at the G0/G1 phase in SKOV3 cells when used at a concentration of 50 nM. Apicidin (3.5 mg/kg every two days, i.p.) prevents decreases in freezing time in contextual fear conditioning tests, indicating a reversal of memory deficits, and accumulation of amyloid-beta (1-40) (?beta40) and ?beta42 in the hippocampus and cortex in an APPswe/PSEN1dE9 transgenic mouse model of Alzheimer's disease.Formal Name: cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]. CAS Number: 183506-66-3. Synonyms: OSI 2040. Molecular Formula: C34H49N5O6. Formula Weight: 623.8. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 221 nm. SMILES: O=C1C([C@@H](C)CC)NC([C@H](CC2=CN(OC)C3=C2C=CC=C3)NC([C@H](CCCCCC(CC)=O)NC([C@@]4([H])CCCCN41)=O)=O)=O. InChi Code: InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-. InChi Key: JWOGUUIOCYMBPV-GTMVXCKXSA-N.
Keywords: | OSI 2040, cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl] |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10575 |
Properties
Application: | HDAC inhibitor |
MW: | 623.8 D |
Formula: | C34H49N5O6 |
Purity: | >90% |
Format: | Crystalline Solid |
Database Information
CAS : | 183506-66-3| Matching products |
KEGG ID : | K11404 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
![]() |
H Phrases: | H300, H310, H330 |
P Phrases: | P260, P262, P264, P270, P271, P280, P284, P301+310, P302+352, P304+340, P310, P320, P321, P330, P361+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed