APD597

APD597 is an orally bioavailable agonist of GPR119 that has EC50 values of 46 and 421 nM for the human and rat receptors, respectively, in a homologous time-resolved fluorescence (HTRF) assay. It increases insulin secretion stimulated by a high, but not low, concentration of glucose in isolated mouse pancreatic beta-cells and in isolated human islets. APD597 (20 mg/kg) increases levels of glucagon-like peptide-1 (GLP-1, Cay-24460) induced by glucose in mice. It also decreases blood glucose levels in an oral glucose tolerance test in mice when administered at doses of 1 and 10 mg/kg and in Zucker diabetic rats at a dose of 3 mg/kg.Formal Name: 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-1-piperidinecarboxylic acid, 1-methylethyl ester. CAS Number: 897732-93-3. Synonyms: JNJ-38431055. Molecular Formula: C21H29N5O6S. Formula Weight: 479.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25mg/mL, DMSO: 25mg/mL, Ethanol: 50mg/mL, Ethanol:PBS (pH 7.2) (1:3): 0.25mg/mL. lambdamax: 311 nm. SMILES: CC(OC(N1CCC(OC2=C(OC)C(NC3=C(C)N=C(S(C)(=O)=O)C=C3)=NC=N2)CC1)=O)C. InChi Code: InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25). InChi Key: WPDCHTSXOPUOII-UHFFFAOYSA-N.