AP26113
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AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50 12087),... more
Product information "AP26113"
AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50 12087), ceritinib (Cay-19374), and CH5424802 (Cay-18516). AP26113 blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants.Formal Name: 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine. CAS Number: 1197953-54-0. Synonyms: Brigatinib. Molecular Formula: C29H39ClN7O2P. Formula Weight: 584.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 284 nm. SMILES: COC1=C(NC2=NC=C(Cl)C(NC3=CC=CC=C3P(C)(C)=O)=N2)C=CC(N4CCC(N5CCN(C)CC5)CC4)=C1. InChi Code: InChI=1S/C29H39ClN7O2P/c1-35-15-17-37(18-16-35)21-11-13-36(14-12-21)22-9-10-24(26(19-22)39-2)33-29-31-20-23(30)28(34-29)32-25-7-5-6-8-27(25)40(3,4)38/h5-10,19-21H,11-18H2,1-4H3,(H2,31,32,33,34). InChi Key: AILRADAXUVEEIR-UHFFFAOYSA-N.
| Keywords: | Brigatinib, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 19778 |
Properties
| Application: | Dual ALK / EGFR inhibitor |
| MW: | 584.1 D |
| Formula: | C29H39ClN7O2P |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 1197953-54-0| Matching products |
| KEGG ID : | K04361 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H361, H372, H410 |
| P Phrases: | P201, P202, P260, P264, P270, P273, P280, P301+310, P308+313, P314, P321, P330, P391, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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