Ansatrienin B

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-alpha-induced expression of intercellular adhesion molecule-1 (ICAM-1, IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil (Cay-14416), cisplatin (Cay-13119), bleomycin (Cay-13877), mitomycin C (Cay-11435), and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A (Cay-21995).Formal Name: N-(cyclohexylcarbonyl)-D-alanine, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester. CAS Number: 82189-04-6. Synonyms: Mycotrienin II, SDZ-115 962. Molecular Formula: C36H50N2O8. Formula Weight: 638.8. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: O=C(N[C@H](C)C(O[C@H]([C@H](C)[C@@H](O)/C(C)=C\CCC1=CC(O)=CC(N2)=C1O)C/C=C/C=C/C=C/[C@H](OC)CC2=O)=O)C3CCCCC3. InChi Code: InChI=1S/C36H50N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,39,41-42H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)/b6-5+,12-7+,18-11+,23-14-/t24-,25+,29-,31-,33-/m0/s1. InChi Key: VVJDHJZQBGWPEQ-UOZMSBJPSA-N.