Amlexanox

Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste. By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton. More recently, amlexanox has been found to inhibit the non-canonical IKK-epsilon and TANK-binding kinase 1.Formal Name: 2-amino-7-(1-methylethyl)5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid. CAS Number: 68302-57-8. Synonyms: AA 673, CHX 3673, Elics. Molecular Formula: C16H14N2O4. Formula Weight: 298.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 244, 287, 348 nm. SMILES: CC(C)C1=CC=C2C(C(C(C=C(C(O)=O)C(N)=N3)=C3O2)=O)=C1. InChi Code: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21). InChi Key: SGRYPYWGNKJSDL-UHFFFAOYSA-N.