AMG 337

AMG 337 is an orally active and selective inhibitor of c-Met kinase activity (IC50 = 1 nM) and adaptor protein Gab-1 phosphorylation, which subsequently blocks downstream PI3K and MAPK pathways. It has been shown to inhibit hepatocyte growth factor-mediated c-Met phosphorylation in PC3 cells (IC50 = 5 nM) and to block tumor growth in a c-Met-dependent xenograft model in mice (ED50 = 0.3 mg/kg). AMG 337 has been used to inhibit cell proliferation in various c-Met-dependent tumor models.Formal Name: 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one. CAS Number: 1173699-31-4. Molecular Formula: C23H22FN7O3. Formula Weight: 463.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL, Ethanol: 10 mg/mL. lambdamax: 209, 249, 285, 344 nm. SMILES: COCCOC1=CN=C(C=CN([C@H](C)C2=NN=C3N2C=C(C4=CN(C)N=C4)C=C3F)C5=O)C5=C1. InChi Code: InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1. InChi Key: DWHXUGDWKAIASB-CQSZACIVSA-N.