Ambroxol

Description: Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract which play an important role in the body's natural defense mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactants act as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents. Target: P450, Autophagy. Smiles: Nc1c(Br)cc(Br)cc1CN[C@H]1CC[C@H](O)CC1. References: Preissner S, et al. Nucleic Acids Res. 2010, 38(Database issue):D237-43.