Ambroxol-d5 (hydrochloride)

Ambroxol-d5 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay38335-500 500 µg -

6 - 10 business days*

104.00€
Cay38335-1 1 mg -

6 - 10 business days*

196.00€
Cay38335-5 5 mg -

6 - 10 business days*

667.00€
 
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol... more
Product information "Ambroxol-d5 (hydrochloride)"
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol (Cay-19377) by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the rat channel). Ambroxol decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM). It decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells when used at a concentration of 100 µM and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells. Ambroxol (30, 60, or 120 mg/kg) increases phenol red secretion, a marker of expectorant activity, in mice. Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.Formal Name: trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol-d5, monohydrochloride. CAS Number: 2741380-71-0. Molecular Formula: C13H13Br2D5N2O . HCl. Formula Weight: 419.6. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: NC(C(Br)=C1)=C(C=C1Br)CN[C@H](CC2([2H])[2H])CC([2H])([2H])[C@]2([2H])O.Cl. InChi Code: InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10,/h5-6,10-11,17-18H,1-4,7,16H2,1H/t10-,11-,/i3D2,4D2,11D,. InChi Key: QNVKOSLOVOTXKF-KAHSTHOTSA-N.
Keywords: trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol-d5, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 38335

Properties

Application: GC-MS, LC-MS, internal standard, quantification, sodium channel blocker
MW: 419.6 D
Formula: C13H13Br2D5N2O . HCl
Purity: >99% deuterated forms (d1-d5)
Format: Solid

Database Information

CAS : 2741380-71-0| Matching products
KEGG ID : K04842 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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