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AM580 is a retinoic acid receptor agonist that is selective for RARalpha (Kd = 8 nM, AC50 = 0.36 nM) compared to RARbeta (Kd = 131 nM, AC50 = 24.6 nM) and RARgamma (Kd = 450 nM, AC50 = 27.9 nM). It demonstrates greater specific binding to RARalpha compared to retinoic acid (Cay-11017), which exhibits little selectivity across RARalpha, beta, or gamma. AM580 has been used in combination with the GSK3beta inhibitor CHIR99021 (Cay-13122) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm. It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.Formal Name: 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-benzoic acid. CAS Number: 102121-60-8. Synonyms: CD336, NSC 608001, Ro 40-6055. Molecular Formula: C22H25NO3. Formula Weight: 351.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 287 nm. SMILES: OC(C1=CC=C(NC(C2=CC(C(C)(C)CCC3(C)C)=C3C=C2)=O)C=C1)=O. InChi Code: InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26). InChi Key: SZWKGOZKRMMLAJ-UHFFFAOYSA-N.
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