AM0902

AM0902 is a transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 = 0.131 µM for the human receptor in a calcium mobilization assay). It is selective for human TRPA1 over human transient receptor potential vanilloid 1 (TRPV1) and TRPV4, rat TRPV1, TRPV3, and transient receptor potential melastatin 8 (TRPM8), and a panel of 40 additional targets at 10 µM. In vivo, AM0902 (10 and 30 mg/kg) reduces the number of tail flinches induced by the TRPA1 agonist allyl isothiocyanate (AITC) in rats.Formal Name: 1-[[3-[2-(4-chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one. CAS Number: 1883711-97-4. Molecular Formula: C17H15ClN6O2. Formula Weight: 370.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 214 nm. SMILES: O=C1C2=C(N=CN2C)N=CN1CC3=NC(CCC4=CC=C(Cl)C=C4)=NO3. InChi Code: InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3. InChi Key: AWJBWNUUODWOKQ-UHFFFAOYSA-N.