Alsterpaullone

Alsterpaullone is a derivative of kenpaullone (Cay-10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3beta (GSK3beta). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3alpha/beta with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Alsterpaullone has been used to inhibit the cytosolic degradation of beta-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer's disease, and to alter cell proliferation or protein expression in various diseases.Formal Name: 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. CAS Number: 237430-03-4. Synonyms: 9-Nitropaullone, NSC 705701. Molecular Formula: C16H11N3O3. Formula Weight: 293.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 223, 245, 297 nm. SMILES: O=C1CC2=C(NC3=C2C=C([N+]([O-])=O)C=C3)C4=CC=CC=C4N1. InChi Code: InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20). InChi Key: OLUKILHGKRVDCT-UHFFFAOYSA-N.