alpha-Phellandrene

alpha-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities. In vivo, alpha-phellandrene (50, 100, and 200 mg/kg, p.o.) reduces carrageenan-induced neutrophil accumulation and leukocyte rolling and adhesion as well as inhibits production of the pro-inflammatory cytokines TNF-alpha and IL-6 in a rat model of air pouch inflammation. It decreases spleen weight and increases macrophage phagocytosis and natural killer (NK) cell cytotoxic activity in a murine WEHI-3 leukemia model. alpha-Phellandrene has antinociceptive effects in mouse models of pain, reducing acetic acid-induced writhing, paw licking in the capsaicin test, and glutamate-induced licking and biting behavior, as well as increases the paw withdrawal threshold following carrageenan-induced inflammation.Formal Name: 2-methyl-5-(1-methylethyl)-1,3-cyclohexadiene. CAS Number: 99-83-2. Synonyms: p-Mentha-1,5-diene, (±)-alpha-Phellandrene. Molecular Formula: C10H16. Formula Weight: 136.2. Purity: >80%. Formulation: (Request formulation change), An oil. Solubility: Benzene: Soluble, Chloroform: Soluble. SMILES: CC1=CCC(C(C)C)C=C1. InChi Code: InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4-6,8,10H,7H2,1-3H3. InChi Key: OGLDWXZKYODSOB-UHFFFAOYSA-N.