alpha-Carotene

alpha-Carotene is a precursor of vitamin A (Cay-20241) that has been found in various fruits and vegetables. It inhibits proliferation of GOTO human neuroblastoma cells more potently than beta-carotene (Cay-16837) and halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc. It is also more potent than beta-carotene in mouse models of skin and lung carcinogenesis and decreases the number of hepatomas in mice with spontaneous liver carcinogenesis when administered in drinking water at a concentration of 0.05%. alpha-Carotene levels are increased in patients with coronary heart disease and are inversely correlated with the risk of estrogen receptor-negative breast cancer.Formal Name: (6'R)-beta,epsilon-carotene. CAS Number: 7488-99-5. Synonyms: all-trans-alpha-Carotene. Molecular Formula: C40H56. Formula Weight: 536.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 241, 281 nm. SMILES: CC1(C)[C@@H](/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)=CCC1. InChi Code: InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+/t37-/. InChi Key: ANVAOWXLWRTKGA-NTXLUARGSA-N.