Aloisine RP106

Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 µM, respectively). It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs.Formal Name: 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine. CAS Number: 496864-15-4. Molecular Formula: C17H19N3O. Formula Weight: 281.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 12 mg/ml. lambdamax: 260, 354 nm. SMILES: COC(C=C1)=CC=C1C2=C(CCCC)C3=NC=CN=C3N2. InChi Code: InChI=1S/C17H19N3O/c1-3-4-5-14-15(12-6-8-13(21-2)9-7-12)20-17-16(14)18-10-11-19-17/h6-11H,3-5H2,1-2H3,(H,19,20). InChi Key: WVMANZPBOBRWCB-UHFFFAOYSA-N.