Alendronate (sodium hydrate)

Alendronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 50 nM for the recombinant human enzyme). It inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM). Alendronate (3 and 10 µM) reduces angiotensin II-induced collagen I synthesis in isolated rat cardiac fibroblasts. It prevents femoral bone mineral density loss in ovariectomized rats when administered at a dose of 5 mg/kg. Formulations containing alendronate have been used in the treatment of osteoporosis and Paget's disease.Formal Name: P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, monosodium salt trihydrate (1:1:3). CAS Number: 121268-17-5. Synonyms: Adronat, Fosamax, G-704650, MK-217. Molecular Formula: C4H12NO7P2 . H6NaO3. Formula Weight: 325.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 0.25 mg/ml. SMILES: NCCCC(P(O)([O-])=O)(O)P(O)(O)=O.[Na+]. InChi Code: InChI=1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12,/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12),/q,+1/p-1. InChi Key: CAKRAHQRJGUPIG-UHFFFAOYSA-M.