AHU377-d4

AHU377-d4 is intended for use as an internal standard for the quantification of AHU377 (Cay-36230, Cay-21473) by GC- or LC-MS. AHU377 is an ethyl ester prodrug form of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.Formal Name: (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid, alpha-ethyl ester. CAS Number: 1884269-07-1. Synonyms: Sacubitril-d4. Molecular Formula: C24H25D4NO5. Formula Weight: 415.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A film. Solubility: Chloroform: Slightly Soluble, DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: C[C@@H](C(OCC)=O)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1. InChi Code: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1/i13D2,14D2. InChi Key: PYNXFZCZUAOOQC-JCZLLWNUSA-N.