AHU377

AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.Formal Name: (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid, alpha-ethyl ester. CAS Number: 149709-62-6. Synonyms: Sacubitril. Molecular Formula: C24H29NO5. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 100 mg/ml. lambdamax: 252 nm. SMILES: C[C@@H](C(OCC)=O)C[C@H](NC(CCC(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1. InChi Code: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1. InChi Key: PYNXFZCZUAOOQC-UTKZUKDTSA-N.