AG126
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and... more
Product information "AG126"
Description: AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 µM. It blocks the production of TNF-alpha in vitro2 and in vivo, attenuating signaling through NF-kappaB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 µM) and platelet-derived GFRK (IC50 > 100 µM). Target: ERK, COX. Smiles: Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O. References: Novogrodsky, A.,Vanichkin, A.,Patya, M., et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264(5163), 1319-1322 (1994).
| Keywords: | AG 126, Tyrphostin AG126 |
| Supplier: | TargetMol |
| Supplier-Nr: | T4092 |
Properties
| Application: | ERK inhibitor |
| MW: | 215.16 D |
| Formula: | C10H5N3O3 |
Database Information
| CAS : | 118409-62-4| Matching products |
| KEGG ID : | K04371 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H311, H331 |
| P Phrases: | P261, P264, P270, P271, P280, P311, P312, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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