AG-13958

AG-13958 is an antagonist of VEGFR2 (Ki = 0.3 nM). It inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs, IC50 = 0.31 nM).Formal Name: N-[2-fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide. CAS Number: 319460-94-1. Molecular Formula: C26H22FN7O. Formula Weight: 467.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C1=CC(C)=NN1C)NC(C=C2NC3=CC=C4C(/C=C/C5=CC=CC=N5)=NNC4=C3)=C(C=C2)F. InChi Code: InChI=1S/C26H22FN7O/c1-16-13-25(34(2)33-16)26(35)30-24-15-19(7-10-21(24)27)29-18-6-9-20-22(31-32-23(20)14-18)11-8-17-5-3-4-12-28-17/h3-15,29H,1-2H3,(H,30,35)(H,31,32)/b11-8+. InChi Key: JXSVVZKPEDIRTN-DHZHZOJOSA-N.