AG-120

AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.Formal Name: (2S)-1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-glycinamide. CAS Number: 1448347-49-6. Synonyms: Ivosidenib. Molecular Formula: C28H22ClF3N6O3. Formula Weight: 583.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 246, 307 nm. SMILES: O=C1CC[C@@H](C(N([C@H](C(NC2CC(F)(F)C2)=O)C3=C(Cl)C=CC=C3)C4=CC(F)=CN=C4)=O)N1C5=NC=CC(C#N)=C5. InChi Code: InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1. InChi Key: WIJZXSAJMHAVGX-DHLKQENFSA-N.