Afzelin

Description: Afzelin (Kaempferol-3-O-rhamnoside) exhibits several cellular activities such as DNA-protective, antibacterial, antioxidant, anti-inflammatory, and UV-absorbing properties, potentially protecting human skin from UVB-induced damage through a combination of UV-absorbing and cellular actions. Afzelin mitigates mitochondrial damage, promotes mitochondrial biogenesis, and reduces levels of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1. Target: Prostaglandin Receptor, PTEN, TNF, Mitochondrial Metabolism, Autophagy, p38 MAPK, Antibacterial. Smiles: C[C@H]1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@@H](O)[C@@H](O)[C@@H]1O. References: Shin SW, et al. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage. PLoS One. 2013 Apr 23,8(4):e61971.