Afzelin

Afzelin is a polyphenolic glycoside flavone that has been found in B. pinnatum and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals with an IC50 value of 6.44 µg/ml. Afzelin is active against S. aureus, P. aeruginosa, S. typhi, C. albicans, C. parapsilosis, and C. neoformans (MICs = 8, 16, 2, 16, 4, and 4 µg/ml, respectively). It inhibits the proliferation of A549, SKOV3, and SK-MEL-2 cells (EC50s = 40.6, 34.5, and 33.9 µg/ml, respectively). Afzelin (26 mg/kg per day) reduces the number of eosinophils, other inflammatory cells, and total cells, as well as the levels of IL-4, IL-5, and IL-13, in bronchoalveolar lavage fluid (BALF) in a mouse model of allergic asthma.Formal Name: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 482-39-3. Synonyms: Kaempferin, Kaempferol 3-O-rhamnoside, Kaempferol 3-O-alpha-L-rhamnopyranoside. Molecular Formula: C21H20O10. Formula Weight: 432.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: OC1=C2C(OC(C3=CC=C(O)C=C3)=C(O[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)C2=O)=CC(O)=C1. InChi Code: InChI=1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1. InChi Key: SOSLMHZOJATCCP-AEIZVZFYSA-N. Origin: Plant/Cyclocarya paliurus.