Aftin-5

Aftin-5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-MR-C0015-M001 1 mg -

3 - 9 business days*

77.00€
AG-MR-C0015-M005 5 mg -

3 - 9 business days*

275.00€
AG-MR-C0015-M025 25 mg -

3 - 9 business days*

935.00€
 
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Roscovitine-related... more
Product information "Aftin-5"
Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).
Keywords: (2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol, Amyloidbeta Forty-Two Inducer 5
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-MR-C0015

Properties

Application: Roscovitine control
MW: 354,5 D
Formula: C19H26N6O
Purity: >98%
Format: Solid

Database Information

KEGG ID : K04520 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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