Afobazole (hydrochloride)

Afobazole is a multi-targeted anxiolytic drug with neuroprotective activities. It binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as monoamine oxidase A (MAO-A, Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay). Afobazole (5 mg/kg) decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice. It decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 0.3 and 3 mg/kg.Formal Name: 6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, monohydrochloride. CAS Number: 173352-39-1. Synonyms: SM-346. Molecular Formula: C15H21N3O2S . HCl. Formula Weight: 343.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 299 nm. SMILES: CCOC1=CC=C(N=C(SCCN2CCOCC2)N3)C3=C1.Cl. InChi Code: InChI=1S/C15H21N3O2S.ClH/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18,/h3-4,11H,2,5-10H2,1H3,(H,16,17),1H. InChi Key: MYSRFAUFQZYTOV-UHFFFAOYSA-N.