Afatinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt,... more
Product information "Afatinib"
Description: Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively. Target: Autophagy, EGFR. Smiles: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4. References: Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15,5(12):3588-99.
| Keywords: | BIBW 2992, Afatinib free base |
| Supplier: | TargetMol |
| Supplier-Nr: | T21312 |
Properties
| MW: | 485.94 D |
| Formula: | C24H25ClFN5O3 |
Database Information
| CAS : | 850140-72-6| Matching products |
| Protein Atlas Nr. : | Adhesion & Structure |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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