AF38469

AF38469 is an inhibitor of sortilin, also known as the neurotensin-3 receptor (NTS3, IC50 = 330 nM). It is selective for sortilin over neurotensin-1 (NTS1), delta-opioid, angiotensin II type 1 (AT1), endothelin A (ETA), and ETB receptors, GPR40, PPARdelta, and matrix metalloproteinase-12 (MMP-12), and the prostaglandin E2 (PGE2) receptor subtype EP1. AF38469 (400 nM) inhibits the epithelial-to-mesenchymal transition (EMT) in, and reduces migration and invasion of, U87 and A172 glioblastoma cells. It also reduces tumor growth in a glioblastoma multiforme mouse xenograft model when administered at a dose of 0.01 g/kg per day.Formal Name: 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-benzoic acid. CAS Number: 1531634-31-7. Molecular Formula: C15H11F3N2O3. Formula Weight: 324.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. lambdamax: 283 nm. SMILES: O=C(C1=C(C(NC2=CC=CC(C)=N2)=O)C=CC(C(F)(F)F)=C1)O. InChi Code: InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21). InChi Key: JWCUSQCZMQIBMR-UHFFFAOYSA-N.