AF-353 hydrochloride

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T85192-10mg	10 mg				7 - 10 business days*		-
TGM-T85192-50mg	50 mg				7 - 10 business days*		-

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Description: This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors,... more

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Product information "AF-353 hydrochloride"

Description: This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 µM) in cell lines that express human P2X3 and P2X2/3 receptors recombinantly. The compound also shows favorable pharmacokinetic properties, with a half-life (t1/2) of 1.63 hours and a time to reach maximum concentration (Tmax) of 30 minutes. Target: Others. Smiles: O(C1=C(C(C)C)C=C(OC)C(I)=C1)C=2C(N)=NC(N)=NC2.Cl

Keywords:	P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353
Supplier:	TargetMol
Supplier-Nr:	T85192

Properties

Application:	P2X3 receptor antagonist
MW:	436.68 D
Formula:	C14H17IN4O2?HCl

Database Information

CAS :	927887-18-1\| Matching products
KEGG ID :	K05217 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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