AF-353 (hydrochloride)

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.Formal Name: 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine, monohydrochloride. CAS Number: 927887-18-1. Molecular Formula: C14H17IN4O2 . HCl. Formula Weight: 436.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml. lambdamax: 231 nm. SMILES: COC1=CC(C(C)C)=C(OC2=C(N)N=C(N)N=C2)C=C1I.Cl. InChi Code: InChI=1S/C14H17IN4O2.ClH/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16,/h4-7H,1-3H3,(H4,16,17,18,19),1H. InChi Key: QRBBKDZPXABQPE-UHFFFAOYSA-N.