ADAMTS-5 Inhibitor

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes. ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2, IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).Formal Name: 5-[[5-[[(4-chlorophenyl)methyl]thio]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene]-2-thioxo-4-thiazolidinone. CAS Number: 929634-33-3. Molecular Formula: C16H11ClF3N3OS3. Formula Weight: 449.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 225, 280, 363 nm. SMILES: ClC1=CC=C(CSC2=C(/C=C3C(NC(S/3)=S)=O)C(C(F)(F)F)=NN2C)C=C1. InChi Code: InChI=1S/C16H11ClF3N3OS3/c1-23-14(26-7-8-2-4-9(17)5-3-8)10(12(22-23)16(18,19)20)6-11-13(24)21-15(25)27-11/h2-6H,7H2,1H3,(H,21,24,25)/b11-6-. InChi Key: CVYPRDPBCXSVBN-WDZFZDKYSA-N.