ACT-709478

ACT-709478 is an inhibitor of T-type voltage-gated calcium channel 3.1 (Cav3.1), Cav3.2, and Cav3.3 (IC50s = 6.4, 18, and 7.5 nM, respectively). It is selective for T-type calcium channels over the L-type calcium channel Cav1.2 (IC50 = 2,410 nM). ACT-701478 (10 mg/kg) reduces the cumulative duration of absence-like seizures in rats. It also reduces the severity of seizures in a rat model of audiogenic seizures when administered at a dose of 100 mg/kg.Formal Name: N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-benzeneacetamide. CAS Number: 1838651-58-3. Molecular Formula: C22H18F3N5O. Formula Weight: 425.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 220 nm. SMILES: O=C(NC1=NN(CC2=CC=C(C#N)C=N2)C=C1)CC3=CC=C(C4(CC4)C(F)(F)F)C=C3. InChi Code: InChI=1S/C22H18F3N5O/c23-22(24,25)21(8-9-21)17-4-1-15(2-5-17)11-20(31)28-19-7-10-30(29-19)14-18-6-3-16(12-26)13-27-18/h1-7,10,13H,8-9,11,14H2,(H,28,29,31). InChi Key: LSYANGLAZUZYFX-UHFFFAOYSA-N.