Acrivastine

Acrivastine is a histamine H1 receptor antagonist with a Ki value of 10 nM in COS-7 cells expressing the human receptor. In vivo, acrivastine (1 mg/kg) completely inhibits response to histamine in guinea pigs. Formulations containing acrivastine have been used for the treatment of seasonal allergies and hay fever.Formal Name: (2E)-3-[6-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-2-pyridinyl]-2-propenoic acid. CAS Number: 87848-99-5. Synonyms: BW 0270C, BW A825C. Molecular Formula: C22H24N2O2. Formula Weight: 348.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: CC1=CC=C(/C(C2=NC(/C=C/C(O)=O)=CC=C2)=C\CN3CCCC3)C=C1. InChi Code: InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+. InChi Key: PWACSDKDOHSSQD-IUTFFREVSA-N.