Aclidinium (bromide)

Aclidinium is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.1, 0.14, 0.14, 0.21, and 0.16 for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at a concentration of 0.1 µM. Aclidinium reduces bronchoconstriction induced by ACh (Cay-23829) in anesthetized guinea pigs when administered via nebulization. Formulations containing aclidinium have been used in the treatment of chronic obstructive pulmonary disease (COPD).Formal Name: (3R)-3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, monobromide. CAS Number: 320345-99-1. Synonyms: LAS 34273, LAS-W 330. Molecular Formula: C26H30NO4S2 . Br. Formula Weight: 564.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.14 mg/ml. lambdamax: 221, 238, 276 nm. SMILES: O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@@H]3C4CC[N+](CC4)(CCCOC5=CC=CC=C5)C3.[Br-]. InChi Code: InChI=1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21,/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2,1H/q+1,/p-1/t20?,22-,27?,/m0./s1. InChi Key: XLAKJQPTOJHYDR-QTQXQZBYSA-M.