Acetyl-beta-methylcholine (chloride)

Acetyl-beta-methylcholine is a muscarinic (M) receptor agonist. In wild-type mice, acetyl-beta-methylcholine decreases heart rate and blood pressure and increases the airway pressure time index, a measure of bronchoconstriction, in a dose-dependent manner. Cardiac and pulmonary responses are abolished in M2 and M3 knockout mice, respectively, suggesting that acetyl-beta-methylcholine acts on cardiac M2 and pulmonary M3 receptors. Formulations containing acetyl-beta-methylcholine have been used to diagnose asthma and to monitor response to asthma therapies.Formal Name: 2-(acetyloxy)-N,N,N-trimethyl-1-propanaminium, monochloride. CAS Number: 62-51-1. Synonyms: Methacholine. Molecular Formula: C8H18NO2 . Cl. Formula Weight: 195.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 210 nm. SMILES: CC(OC(C[N+](C)(C)C)C)=O.[Cl-]. InChi Code: InChI=1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5,/h7H,6H2,1-5H3,1H/q+1,/p-1. InChi Key: JHPHVAVFUYTVCL-UHFFFAOYSA-M.