Acepromazine (maleate)

Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine (Cay-16129), and a dopamine receptor antagonist. It also binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine (Cay-23829, IC50 = 840 nM). Acepromazine inhibits morphine-induced vomiting in dogs. It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively). Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.Formal Name: 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-ethanone, mono-2Z-butenedioate. CAS Number: 3598-37-6. Synonyms: ACE, Acetylpromazine, NSC 264522. Molecular Formula: C19H22N2OS . C4H4O4. Formula Weight: 442.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1mg/mL, DMSO: 3mg/mL, Ethanol: 2mg/mL, PBS (pH 7.2): 2mg/mL. lambdamax: 242, 278 nm. SMILES: CN(C)CCCN1C2=C(C=CC(C(C)=O)=C2)SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19,5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: FQRHOOHLUYHMGG-BTJKTKAUSA-N.