Ac-WLA-AMC

Ac-WLA-AMC is a fluorogenic substrate for the beta5c subunit of the 20S proteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the beta5c subunit of the 20S proteasome. AMC displays excitation/emission maxima of 351/430 nm, respectively.Formal Name: N-acetyl-L-tryptophyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alaninamide. CAS Number: 1104011-59-7. Synonyms: Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin, Ac-Trp-Leu-Ala-AMC. Molecular Formula: C32H37N5O6. Formula Weight: 587.7. Purity: >95%. Emission: 430 nm. Excitation: 351 nm. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mM. SMILES: O=C1C=C(C)C2=C(C=C(NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC3=CNC4=C3C=CC=C4)NC(C)=O)=O)=O)C)=O)C=C2)O1. InChi Code: InChI=1S/C32H37N5O6/c1-17(2)12-26(37-32(42)27(35-20(5)38)14-21-16-33-25-9-7-6-8-24(21)25)31(41)34-19(4)30(40)36-22-10-11-23-18(3)13-29(39)43-28(23)15-22/h6-11,13,15-17,19,26-27,33H,12,14H2,1-5H3,(H,34,41)(H,35,38)(H,36,40)(H,37,42)/t19-,26-,27-/m0/s1. InChi Key: PIJMRHCPKXLMIS-DOYMOWJKSA-N.